Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. The effect of pet ownership on house dust microbial communities. Role of the gut microbiota in defining human health. Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. Development of a standardized approach for environmental microbiota investigations related to asthma development in children. In addition, we have developed novel ex vivo assays to assess the capacity of human microbiota, specific microbial species or their products to elicit host immune responses ex vivo, providing an objective assessment of their immunomodulatory capacity. Enteric Virome and Bacterial Microbiota in Children with Ulcerative Colitis and Crohn's Disease. Association between cesarean delivery types and obesity in preadolescence. Current understanding of the human microbiome. Fetal and early postnatal lead exposure measured in teeth associates with infant gut microbiota. A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations. Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort. Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. Fecal microbial therapy: promises and pitfalls. Bacterial biogeography of adult airways in atopic asthma. Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis. Persistent infection with Pseudomonas aeruginosa in ventilator-associated pneumonia. We have developed and made publicly available custom scripts and novel tools to facilitate such analyses. Promotion of Epithelial Barrier Integrity Via Probiotic-derived Products. Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls. Other studies examine the contribution of the gut microbiome to distinct respiratory phenotypes of asthma. Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV - implications for anti-PcrV immunotherapy. Escherichia coli biofilms formed under low-shear modeled microgravity in a ground-based system. Induction of intestinal Th17 cells by segmented filamentous bacteria. New Insights. Professor. Motility and biofilm formation of the emerging gastrointestinal pathogen Campylobacter concisus differs under microaerophilic and anaerobic environments. Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile. Distinct lung microbiota associate with HIV-associated chronic lung disease in children. Probiotic strategies for treatment of respiratory diseases. Gut Microbiota and Allergic Disease. Role of integrin alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa. Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance. Distinct Nasal Airway Bacterial Microbiota Differentially Relate to Exacerbation in Pediatric Asthma. Heterogeneity of Microbiota Dysbiosis in Chronic Rhinosinusitis: Potential Clinical Implications and Microbial Community Mechanisms Contributing to Sinonasal Inflammation. Effect of chromate stress on Escherichia coli K-12. The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients. Susan.Lynch@ucsf.edu +1 415 476-6784 Our human microbiome research program focuses on the gastrointestinal and airway microbiomes and their influence on the development and maintenance of chronic inflammatory disease.
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