This course was created by Professor Barbara Bain at St Mary’s Hospital. Faculty of Medicine at Imperial College London is a world leader in medical research and educating the next generation of healthcare professionals. Other causes of dyserythropoiesis include congenital dyserythropoietic anaemia, sickle cell disease (particularly in conditions of “haemopoietic stress”), thalassaemia, various infections (including malaria and leishmaniasis) and arsenic toxicity. 5 0 obj << /Type /Font /Subtype /Type1 /FirstChar 32 /LastChar 177 /Widths [ 281 343 552 666 520 916 781 281 416 416 510 666 343 458 343 281 520 520 520 520 520 520 520 520 520 520 343 343 666 666 666 458 927 781 781 802 875 750 687 843 875 406 406 781 687 1010 791 875 729 864 770 656 739 833 729 1031 781 729 687 395 281 395 583 500 333 562 604 520 614 520 354 552 625 333 312 552 312 979 625 572 614 614 479 458 375 625 541 770 552 541 510 395 583 395 520 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 520 510 0 0 0 0 0 0 0 0 0 0 0 0 0 666 ] /Encoding /WinAnsiEncoding /BaseFont /CIHFLB+AdvPLB /FontDescriptor 12 0 R >> endobj This is a collection of morphology photos I, and other contributors, have taken ourselves - hence the slightly scattered subject matter. Originally written in the Italian language by two world leaders in the field, the book has been expertly translated by the renowned haematologist and teacher, Barbara Bain. Places are only allocated when payment has been received. H�,UiTW��^�x�T�H?M0. Ineffective haemopoiesis is recognised from the usual discrepancy between a hypercellular bone marrow and peripheral cytopenia. 2020 Imperial College London, Multidisciplinary networks, centres and institutes, Changes to the Faculty's academic organisational structure from 2019/20, Our vision for heart and lung research in north west London, Surgical Design, Technology and Innovation, What students say about Follow My Footsteps, Information for current staff and students, Your personal professional online presence at Imperial, Promoting Clinical Research and Clinical Trials Online, Risk assessment proformas and examples for out of hours work, Faculty process for selection of University Reps, Approval process: new Master's programmes, Approval process: non-credit bearing short courses, Master's Application Reassignment System (MARS), Morphology update for biomedical scientists and first year senior trainees, Register and pay - September 2020 session, Laboratory aspects of haemoglobinopathy diagnosis, Imperial College Academic Health Science Centre. Possible dyserythropoietic features include nuclear irregularity or lobulation, bi- or multinuclearity and megaloblastosis (nuclear immaturity in relation to the degree of maturation of the cytoplasm). The information you provide is kept in a secure location and is only made available to authorised staff within Imperial College London. Acquired conditions of relevance include HIV infection, administration of G-CSF (granulocyte colony-stimulating factor) and the effects of various drugs including chemotherapeutic and immunosuppressive agents. Imperial academics share insights on Environment Bill with parliamentarians, Cannabis pain insights and kidney disease discoveries: News from the College, Imperial and Twig join forces to contribute to UNICEF's Learning Passport, A one-day course that aims to enhance skills in peripheral blood morphology, Location3rd Floor LaboratoriesCommonwealth BuildingHammersmith Hospital CampusDu Cane RoadLondon W12 0NN, General enquiriesAmanda Smitha.sale@imperial.ac.uk+44 (0)20 3313 4017. Alison Hadfield, a Healthcare Science Section Leader in core haematology from the Newcastle upon Tyne Hospitals NHS Foundation Trust, presents a vitamin K-deficiency patient case study. Early booking is advised, particularly for the two-day course, as courses are often booked out. It is the result of an increased rate of death of haemopoietic cells by apoptosis within the bone marrow. Originally written in the Italian language by two world leaders in the field, the book has been expertly translated by the renowned haematologist and teacher, Barbara Bain. In patients with sideroblastic erythropoiesis, vacuolation and defective haemoglobinisation of erythroblasts may be apparent; an iron stain showing ring sideroblasts is confirmatory (but remembering that sideroblastic erythropoiesis can also be due to lead poisoning, copper deficiency and inherited sideroblastic anaemia). in Digital Cell Morphology CellaVision is the world leader in digital cell morphology. W12 0HS, Information for Council and Committee Observers, Diversity and inclusion in biomedical science, Setting up a new branch or discussion groups, Regional, branch and discussion group AGMs, A day in the life of an external verifier. All cases are reviewed collectively after the participants have made their own diagnoses. It is now taught by Professor Barbara Bain and Dr Vishal Jayakar. The blood count shows cytopenia (one or more of anaemia, neutropenia and thrombocytopenia) and in addition can show an increased MCV and a bimodal histogram of red cell size (in cases with sideroblastic erythropoiesis). Telephone: 7607 7191 © Location. The only way to prepare is plenty of practice and if possible doing so using the same microscope you will use for the exam. It covers all aspects of peripheral blood and bone marrow morphology. Share this page: Tweet. In such cases a search should be made for Pappenheimer bodies. If cancellations are received more than 14 days before the course, a refund will be given after deduction of a handling charge. n��(�ڍ,�"Bv�}G����P�ٷe�TD��EeQH&'�$�qИ���3S�̟:u��[߽���{2�Ȁ��d Other causes of dysgranulopoiesis include the inherited conditions mentioned above and also myelokathexis (an inherited condition with morphologically abnormal granulocytes). This course was created by Professor Barbara Bain at St Mary’s Hospital. Our expertise in translating biomedical discoveries into clinical practice benefits patients worldwide. The information you provide is kept in a secure location and is only made available to authorised staff within Imperial College London. There are also several key lectures, and photographs of all cases, as well as PowerPoint presentations of several lectures, are provided to the participants for the purposes of private study after the course. Bain BJ and Bhavnani M (2011) The gray platelet syndrome. 13 0 obj << /Filter /FlateDecode /Length 2394 /Subtype /Type1C >> stream Du Cane Rd, It is important not only to raise the suspicion of MDS but to be constantly aware of the possibility of conditions that can simulate it. We do not share your information with any other parties. Less specific, but also diagnostically useful, is the presence of megakaryocytes that are mainly of normal size but are hypolobated. Bain BJ (2014) Interactive Haematology Imagebank, 2 nd Edn, Wiley‒Blackwell, Oxford 2020 Imperial College London, Multidisciplinary networks, centres and institutes, Changes to the Faculty's academic organisational structure from 2019/20, Our vision for heart and lung research in north west London, Surgical Design, Technology and Innovation, What students say about Follow My Footsteps, Information for current staff and students, Your personal professional online presence at Imperial, Promoting Clinical Research and Clinical Trials Online, Risk assessment proformas and examples for out of hours work, Faculty process for selection of University Reps, Approval process: new Master's programmes, Approval process: non-credit bearing short courses, Master's Application Reassignment System (MARS), Register and pay - September 2020 session, Laboratory aspects of haemoglobinopathy diagnosis, Morphology update for biomedical scientists and first-year senior trainees, Imperial College Academic Health Science Centre. Copper deficiency (including that due to zinc excess) can simulate MDS by causing pancytopenia, macrocytosis, neutropenia and sideroblastic erythropoiesis; anaemia can also be microcytic or normocytic. Bone marrow morphology is also useful; although megaloblastic erythropoiesis can be a feature of MDS, giant metamyelocytes are quite uncommon as a feature. The differential diagnosis of MDS includes megaloblastic anaemia due to deficiency of vitamin B12 or folic acid. Microscopy, case reviews and lectures. The presence of micromegakaryocytes provides very specific evidence of a haematological neoplasm so is useful in the diagnosis of MDS. Chemotherapeutic agents can simulate MDS by causing pancytopenia and dysplasia; in the case of folic acid antagonists and drugs interfering more directly with DNA synthesis, there is megaloblastosis. We do not share your information with any other parties. Morphology in the diagnosis of red cell disorders BARBARA J. BAIN Department of Haematology, Imperial College Faculty of Medicine, St Mary’s Hospital, Praed Street, London W2 1NY, UK Abstract Despite the advances in automated blood cell counting, the blood film retains a crucial role in the diagnosis of red cell disorders. This thesis was carried out at CellaVision, a company within digital blood analysis, with the aim of investigating the possibility of autovalidation of blood cells using neural networks. Particular thanks to @Promyelocyte13 generously contributed her photos to this collection. Event website, Hammersmith Hospital Your data is not used for any purpose other than for confirming bookings, payments and to contact you relating to the course you have booked onto. Level 2, Faculty BuildingSouth Kensington CampusLondon SW7 2AZ, UKContact us. The CDC have a great set of malaria photos. megaloblastic anaemia) and other causes of dysplastic haemopoiesis (e.g. Less common dysplastic forms are macropolycytes and granulocytes with pseudo-Chédiak‒Higashi granules. Barbara Bain is Professor of Diagnostic Haematology at Imperial College London and a consultant at St Mary’s Hospital, London. The course is microscopy-based using peripheral blood and bone marrow films and a small number of trephine biopsy sections. The blood film is useful in making the distinction since oval macrocytes and hypersegmented neutrophils are much more common in the vitamin deficiencies than in MDS. Free resources for morphology: Barbara Bain of course has published a wealth of books, most labs will have copies of these that can be borrowed. Please note that because of catering and course material expenses, cancellations received within two weeks of the course date will not receive a refund.

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